![]() Midazolam serum concentrations were similar in both groups.įlumazenil in a dose of 0.15 mg is a safe drug that reverses the sedative effect of midazolam.BZDs are safer than older sedative-hypnotic agents, such Supplemental dose may be necessary after 20-30 minutes Onset of action: 1-2 minutes Peak effect: 5 min Duration of effect: 30-45 minutes elderly Mixing benzos with opioids and alcohol is a serious overdose risk factor, which can cause severe sedation, slowed breathing, coma, However, they have a high potential for abuse, especially when someone drinks after taking them or uses them alongside other substances. Reversal was not seen in any of the patients who received placebo. Reversal of sedation was observed in 14 of 15 patients who received flumazenil, and resedation occurred in seven of these patients. Midazolam concentrations in serum were measured at the time of cessation of the midazolam infusion and at 30, 60, and 120 mins later. Sedation levels were measured hourly during the infusion at the end of the infusion and at 5, 15, 30, 60, and 120 mins after cessation of the midazolam infusion. At the end of the sedation period, either flumazenil or placebo was administered to all the patients in a double-blind, randomized fashion, and the effects were observed. ![]() Twenty-nine patients received supplementary narcotics. ![]() Thirty ICU patients requiring artificial ventilation for greater than 12 hrs were studied.Īll patients received a midazolam infusion for sedation. ![]() ICU of a tertiary, university-affiliated teaching hospital. Prospective, double-blind randomized study. ![]() To demonstrate the efficacy of flumazenil in reversing the sedative action of midazolam in ventilated intensive care patients. ![]()
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